Process bioreactor / fermentor biorREACTOR 8

for the pharmaceutical industryautomatedfor parallel synthesis

The 2mag bioREACTOR is a new developed, space-saving and user-friendly bioreaction block with up to 8 parallelized mini reactors. The high parallelization allows an easy realization of high-throughput fermentations in the biotechnological, chemical or pharmaceutical research. This strongly reduces development time and costs for new production processes. Miniaturization into the low milliliter scale (8-15 ml) provides a significant saving of material and process costs. The 2mag bioREACTOR is characterized by a precise temperature control, an exactly con-trollable stirring speed with automatic stirrer monitoring as well as precise non-invasive real-time measurement of pH and dissolved oxygen (DO). Gassing and mixing of the reaction vessels is provided by the gas inducing, inductive stirring elements. The sterile headspace aeration prevents cross and external contaminations and allows cultiva-tion of aerobic and anaerobic microorganisms. An easy and secure scaling-up of the results into production scale can be ensured by precisely defined engineering parameters and the comparable power and oxygen input (kLa > 0,4 s-1) to well-established stirred tank reactors. The bioREACTOR can be operated as standalone or fully automated by integration into a pipetting robot. Parallelisation The 2mag bioREACTOR is available in two model variants with 8 or 48 parallel reaction vessels. A still higher parallelisation can be achieved by simoultaneous use of several bioREACTOR units. These can be controlled via an intelligent central software and important process parameters (pH ans DO) can be monitored in real time.