FT-IR spectrometer CONFOCHECK

monitoring

The CONFOCHECK is a dedicated FTIR system for the investigation of proteins in water. Its specific configuration facilitates a fast data acquisition (ca. 30 sec. per sample) with a high sample throughput controlled by an extremely user-friendly software interface. FTIR Protein Applications: • Protein quantification • Detection of conformational changes • Protein dynamics (temperature induced conformational changes) • Monitoring of conformational changes during protein aggregation, precipitation and crystallization • Determination of the secondary structure • Quantification of all kind of solutes in aqueous samples (buffers, excipients, detergents) Typical Applications in Pharma: • Pre-formulation and formulation development: Analysis of the influence of the formulation on protein stability • Stability studies (stress tests): Influence of pH, temperature, mutation, etc. on the protein stability • Quality control: Check of protein concentration, structure on correct product composition (buffer, excipients) in production environment • Binding studies: Analysis of the impact of ligand-binding on the protein structure