Process bioreactor Corning® Ascent® FBR

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Improve Scale-up of Adherent Cells for Bioproduction A major challenge for manufacturing adherent cells for advanced therapies is producing the large quantities of cells needed in a cost-effective manner. To address the need for a more efficient solution, Corning developed the novel Ascent FBR System, a fixed bed bioreactor system designed to combine the benefits of adherent bioproduction platforms with the scale and automation of suspension manufacturing systems. Description The Ascent FBR: • Features en innovative bioreactor designed to enable uniform media flow and uniform high-density cell growth • Demonstrated to achieve greater than transfection efficiency and high AAV-GFP vector yield'm2. which can reduce required runs and result in substantial cost savings • Enables viable cell harvests for seed train end total viral particle capture and e path for other applications, such as stem cell therapy workflows • Multiple Ascent FSR formats, trom a 1 m2 benchtop system to 11000 m2 production system, are planned to help create e stable and well-defined manufacturing process • Allows for the use of chemical (detergent) or mechanical (freezefthew, microfluidization) cell lysis methods for the release of cell-associated viral vectors