MicAO 3DSR is an adaptive optics device specifically designed for single molecule localization microscopy (SMLM) methods such as photoactivation localization microscopy (PALM), stochastic optical reconstruction microscopy (STORM) and single particle tracking (SPT). The high optical transmission of MicAO 3DSR and the ability to correct aberrations enables your microscope setup to detect more photons from the sample after correction of aberrations. This helps increasing the localization precision (resolution) of SMLM methods. Moreover, with MicAO 3DSR you can introduce aberration-free astigmatism for the most precise 3D SMLM imaging on the market.MicAO 3DSR has been developed for an easy implementation of adaptive optics on any inverted microscope frame therefore it is a perfect solution for inexperienced users or imaging facilities. The device is simply inserted between the microscope side port and the imaging camera. MicAO 3DSR functions as an image relay therefore does not influence the function of additional devices in the optical setup, such as dual color view devices and microscope port splitters.