Customized Impingement jets mixing skids for Large Production Scale
Impingement Jets Mixing (IJM) Skids for high flow production of nanoparticles (LNP, microemulsions, etc.)
The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on the customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.
Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.
The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.
The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:
up to 16 KNAUER high-pressure dosing pumps 80P
up to 16 Coriolis flow meters
up to 8 KNAUER IJM mixers
Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
Outlet manifold for LNP solution
Back-seal washing system
The frame (stainless steel system 1.4301)
Installation & familiarization by KNAUER