The Hamilton PRP-X100 - 125/4.0 IC anion column is a robust separation column based on a polystyrene-divinylbenzene copolymer. It is especially suited for separation of chloride, nitrate, and sulfate without chemical suppression. Fluoride can also be determined if the cations are removed first with an H+ cartridge. The Hamilton PRP-X100 - 125/4.0 is also the separation column of choice for the determination of silicate. The column excels with a very good price-performance ratio.