Dissolution tester PT-DR

for medical agentsfor pharmaceutical applications

Dispersion Releaser – Release Apparatus for Nano- and Microformulations The Dispersion Releaser PT-DR is a dialysis-based apparatus for the release testing of nanomedicines, microformulations and semi-solid dosage forms within a standard dissolution tester. It is composed of a sample holder cell serving as the donor compartment for dispersed dosage forms. A dialysis membrane is disposed around this housing. This donor chamber is agitated by a paddle stirrer that is connected to the USP Apparatus 2. Application of the Dispersion Releaser The Dispersion Releaser is connected to the dissolution tester by a special coupling directly affiliated to the stirrer shaft. This way the Dispersion Releaser can be hooked to the coupling and as well easily removed from the stirrer shaft for preparation and cleaning purposes. This ensures a direct transfer of the stirring movements to the stirrer of the Dispersion Releaser. Basically the Dispersion Releaser consists of a donor and acceptor compartment. The donor compartment is a cylindrically construction which contains the substance to be tested. This construction is surrounded by a membrane, fixed through two O-rings, which acts as barrier between donor and acceptor compartment. In the inside of the donor compartment is a small paddle, with integrated magnets, directly influenced and controlled by the stirrer shaft of the dissolution tester. Through the integrated magnets an external magnetic stirrer, located at the bottom of the donor, is driven to mix the media in the acceptor compartment.