Semi-Automated Dissolution Test System
The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-120SP system is composed of a PTWS 120D or PTWS 120S staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including in-situ sampling probes, a PT-SP8 syringe pump, and a PTFC-2/8 fraction collector. In this configuration the sampling probes are always immersed into the media (in-situ). This procedure is widely used.
Semi Automated Tablet Dissolution Testing
Semi-automated in this case means auto sampling for a dissolution test instrument at pre-programmed times. Automating this step alone eases the dissolution job a lot. After all tablets have been dropped, the dissolution test proceeds automatically and all samples are simultaneously removed from each connected vessel. The sample is delivered into a connected fraction collector by a peristaltic-, or the PT-SP syringe pump.
These systems do not require any external PC software to control them (the WinDiss ARGUS dissolution software package can be used optionally). Sampling information is entered directly at the connected PTWS 120D/S dissolution testing instrument.All Pharma Test tablet dissolution test instruments can be upgraded with a pump and PTFC-2/8 fraction collector or DSR-M sampling robot.
Automated Sampling
The perception of automation in dissolution testing differs greatly from user to user. The most labor intensive stage is taking samples at the specified time periods as found in the company SOP (Standard Operating Procedure).