Batch bioreactor Ambr® 250

processlaboratoryfor the pharmaceutical industry

Ambr® 250 High Throughput Perfusion is a parallel bioreactor system for rapid development of scalable perfusion processes using 100 – 250 mL single-use bioreactors and a fully automated liquid handling platform. The system supports the typical range of hollow fibre cell retention applications, with up to 24 fully single-use perfusion bioreactors in parallel. This step-change in perfusion process development capability dramatically accelerates the optimization of intensified cell culture processes leading to lower production volumes and reduced cost of goods. The system is capable of running in perfusion culture or fed-batch mode, depending on the type of ambr bioreactors installed, ideal for a wide range of biopharma and industrial biotech applications such as: • Media development • Scale-down model development Ambr® 250 High Throughput single-use perfusion bioreactors are available including all components required for perfusion culture, fully assembled and irradiated. Single-use perfusion bioreactors significantly reduce staff time needed for set-up and cleaning, and enable rapid system turnaround, increasing system utilization efficiency and reducing development timelines. Fully assembled and irradiated components further reduce set-up time and minimize risk of lost experiments. The single-use perfusion bioreactor includes a high-efficiency multi-hole sparger capable of supporting very high cell densities. Two dip tubes allow flow of culture to and from the perfusion pump and filter, plus automated bleeding and bleed-to-level functions.