Liquid chromatography system Resolute® BioSC series

processfor pharmaceutical applicationslaboratory

Biopharma companies are facing major challenges today, with rising drug production costs as well as lower production volumes due to an unpredictable demand. To achieve the necessary reductions in both costs of goods (CoG) and infrastructure and operational costs, they integrate Process Intensification strategies into their production schemes. Resolute® BioSC Pilot is a multi-use chromatography system, that can simultaneously and continuously operate three chromatography separations, either in batch or multi-column chromatography mode, including viral inactivation and in-line buffer preparation. The chaining of multiple unit operations together results in a compact and intensified process. The Resolute® BioSC platform is a chromatography system designed to purify biologics (mAbs, recombinant proteins, blood factors…) from the process development to Commercial Manufacturing scale. Resolute® BioSC Pilot can operate simultaneously and continuously three chromatography separations, including viral inactivation and in-line buffer preparation. The chaining of multiple processes results in a streamlined and intensified process. • Integrated viral Inactivation Enables full automation and integration of the VI, as well as chromatography process management with a single skid • In-line buffer preparation Automatically prepares solutions with the right combination of pH, conductivity, and concentration from mother solutions. These three parameters are continuously monitored and controlled by a dedicated algorithm to guarantee accuracy and fast response.