Sample analysis system Tm

automatic

Tm analysis systems can accelerate the development process and improve the quality of oligonucleotide therapeutics. Control by LabSolutionsTM software enables compliance with ER/ES-related regulatory requirements and improves the efficiency of analyzing the thermal stability (Tm analysis) of nucleic acids. Tm analysis serves an important role in checking the thermal stability and sequence of nucleic acids. In Tm analysis, heat is applied to the nucleic acids in double-strands. Then, the change in absorbance (melting curve) that occurs as the temperature increases and the strands dissociate into single strands is measured. The melting temperature (Tm value) is determined as the temperature where the mole fractions of single and double strands are equal. Tm analysis systems comprise a spectrophotometer, TMSPC-8i 8-cell thermoelectrically temperature-controlled cell holder, and LabSolutions UV-Vis Tm software. They can automatically determine Tm values based on melting curve measurements using the average method or derivative method. LabSolutions UV-Vis Tm can provide the industry’s highest data integrity levels when linked to a LabSolutions DB/CS system, which has an extensive track record from use with LC, GC, and many other analytical instruments. This micro multi-cell can be used to measure eight samples at the same time using the same measurement conditions. In addition to previous micro multi-cell models with a 10 mm optical path length (with a 100 μL minimum sample volume) for satisfying high-sensitivity measurement needs, a new model with a 1 mm optical path length