Mass spectrometer

Q-TOFlaboratorychemical

The OAD-TOF system is a Q-TOF LCMS that realizes OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technology. It allows the analysis of the position of carbon-carbon double bonds in lipids and other organic compounds. Combined with the LCMS-9050, which boasts world-class high mass accuracy and fast polarity switching, it enables the creation of innovative applications. Introduction of neutral radicals in positive and negative modes Effortless operation and reliable results Diverse analytical needs can be met The OAD-TOF system is equipped with an OAD RADICAL SOURCE I, which enables Oxygen Attachment Dissociation (OAD) analysis, an innovative fragmentation that utilizes Shimadzu’s proprietary radical reaction. It can measure fragment ions that cannot be obtained by conventional collision-induced dissociation (CID), where ions are fragmented by collision with an inert gas such as argon or nitrogen. The irradiating oxygen radicals specifically oxidize/dissociate double bonds between carbons, which is useful for structure estimation of organic compounds such as lipids. The technique can be applied to monovalent ions and negative ions, which have been difficult to fragment using radical reactions by electrons and anions, and provides completely new structural information What is OAD (oxygen attachment dissociation) CID preferentially dissociates weak chemical bonds. In the case of lipids, CID can determine the basic structure of lipids and polar groups, and the carbon composition of side chains (number of carbons and double bonds). With OAD, on the other hand