The ISC airbag-type inner support clamp is an innovative flexible clamp that imitates the self-defense shape of puffer fish and is bionic designed. By filling the flexible air bag with air with a certain pressure, the expansion is realized and the inner support-type grasping is completed. Since the input air pressure can be precisely controlled, the clamping force exerted by the fixture on the workpiece can be controlled, and the workpiece is not easily damaged.