Rapid liquid phase protein chromatograph

process

Designed to improve productivity in protein A affinity purification of monoclonal antibodies, GORE Protein Capture Devices provide high binding capacity at short residence time. Traditional affinity chromatography technology has not kept pace with increased titers and other upstream process improvements, leading to bottlenecks and lower productivity in downstream protein A purification. To shorten processing times, traditional resin-based protein A is often over-sized or underutilized – simply to keep up.* Increase productivity: GORE Protein Capture Devices with Protein A utilize a unique membrane solution that provides a binding capacity advantage at high flow rates and improves the speed of purification versus traditional protein A resin technologies. Compare our Dynamic Binding Capacity (DBC) to that of agarose bead-based columns: GORE Protein Capture Devices are approximately 6–10x faster than traditional (agarose bead-based) chromatography methods, which operate at typical residence times of 3–5 minutes (180–300 seconds). Designed for affinity purification in early drug discovery screening, late stage optimization, process development, clinical and routine bioprocessing for monoclonal antibodies (mAbs) next-generation molecules that utilize the Fc region for Protein A binding The columns are compatible with standard chromatography systems. GORE Protein Capture Devices with immobilized Protein A* can improve throughput and yields in downstream purification by reducing overall process time through a combination of increased binding capacity and fast flow rates.